GSK2890457

**GSK2890457** is an investigational, orally administered nutritional-agent mixture developed by GSK for metabolic disease research. It contains oligofructosaccharide, apple pectin, blackcurrant extract, and oleic acid in a 5:5:2:3 ratio. The formulation was designed to modulate nutrient sensing, gut microbiota-related metabolism, and endogenous gut-peptide release to improve body weight and glycemic control. It showed marked synergistic effects with a long-acting GLP-1 receptor agonist in obese and diabetic mouse models, but did not produce clinically meaningful weight-loss or glycemic benefits in a six-week study in people with type 2 diabetes receiving liraglutide or metformin. ([journals.plos.org](https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0153151))

Other names

GSK457GSK-457GSK 457