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GSK3536867

Development stage: Phase 1
Lead developer: GSK
Modality: Vaccines & Immunotherapeutics

Overview

**GSK3536867** is a bivalent conjugate vaccine candidate developed by GSK for the prevention of Salmonella infections, specifically targeting typhoid and paratyphoid A. It aims to induce immune responses against both serotypes through conjugation technology, which enhances immunogenicity of bacterial polysaccharides. The program reached Phase I clinical trials but was discontinued as part of GSK's pipeline adjustments to focus on higher-priority assets.[2][9][11][14]

Other names: bivalent Typhoid and Paratyphoid A conjugate vaccine

Targets

Salmonella Paratyphi A O-antigen-specific B-cell receptor (SPA O-antigen BCR)Vi antigen (Vi capsular polysaccharide)Vi polysaccharide-specific B-cell receptorCD209 (Dendritic cell-specific intercellular adhesion Molecule-3-Grabbing non-integrin)Paratyphi A antigen (Salmonella Paratyphi A antigen)

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