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GSK3903133A
- Development stage
- Phase 1
- Lead developer
- GSK
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, mRNA Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GSK3903133A is a self-amplifying RNA (saRNA) vaccine developed by GSK for the prevention of rabies. The vaccine encodes the rabies virus glycoprotein G antigen and is formulated with a cationic nanoemulsion (CNE). It acts as an immunostimulant to induce protective antibody responses against rabies. Preclinical studies demonstrated durable expression and robust immunogenicity in animal models, while a phase 1 clinical trial evaluated its safety and immunogenicity in healthy adults. This candidate represents one of the first saRNA vaccines to enter human trials for infectious disease prevention[1][2][5].
- Other names
- GSK 3903133AGSK3903133AGSK-3903133ARG-SAM [CNE] vaccine
02
Targets
PRR (Pattern recognition receptors)
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