Drug intelligence / Profile preview

GSKVX000000030825

Development stage
Phase 2
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Intramuscular
01

Overview

GSKVX000000030825 is an investigational biological component of a recombinant protein-based immunotherapy developed by GSK for the treatment and prevention of herpes simplex virus (HSV) infections, specifically genital herpes caused by HSV-2. It is currently being evaluated in Phase I/II clinical trials (e.g., trial 2024-510571-37-00) as part of a multi-component vaccine candidate that typically includes recombinant viral glycoproteins and a proprietary adjuvant system such as AS01. The immunotherapy is designed to elicit robust humoral and cellular immune responses to reduce viral shedding and the frequency of clinical recurrences in infected individuals, while also providing potential prophylactic protection in seronegative adults.

02

Targets

gD (HSV-2 glycoprotein D)TLR4 (Toll-like receptor 4)

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