Drug intelligence / Profile preview

GSKVX000000034798 (GSK)

Development stage
Unknown
Lead developer
GSK
Modality
mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

GSKVX000000034798 is an mRNA-based vaccine candidate developed by GSK for the prevention of seasonal influenza. It is one of several mRNA constructs being evaluated as part of a multivalent seasonal influenza vaccine program. The vaccine utilizes messenger RNA technology to encode for specific influenza viral antigens, such as hemagglutinin, which are then expressed by the recipient's cells to induce a protective immune response. As of early 2025, it is in Phase 2a clinical development (e.g., trial 2025-522278-35-00) to evaluate its safety and immunogenicity in adults compared to standard inactivated influenza vaccines.

02

Targets

DDX58 (Retinoic acid-inducible gene I protein)TLR7 (Toll-like receptor 7)HA (Hemagglutinin)

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