GsMTx4-D

GsMTx4-D is a modified peptide inhibitor of mechanosensitive ion channels (MSCs), specifically the D-enantiomer of the peptide GsMTx4 originally isolated from the venom of the tarantula Grammostola spatulata. By utilizing D-amino acids, the peptide exhibits improved pharmacodynamics and resistance to proteolysis compared to its L-amino acid counterpart, resulting in a favorable half-life of approximately one week. GsMTx4-D is being investigated for the treatment of Duchenne muscular dystrophy (DMD) and cardiac ischemic reperfusion injury. It works by blocking MSCs that are dysregulated under pathological mechanical stress, thereby reducing muscle mass loss, susceptibility to contraction-induced injury, and cardiac infarct size without affecting normal cardiac output or electrical activity.

Other names

D-GsMTx4D-GsMTx-4D-GsMTx 4GsMTx4 (D-form)