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Gu-Ben-Fang-Xiao-Tang
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
Gu-Ben-Fang-Xiao-Tang (GBFXT) is a traditional Chinese medicine (TCM) formula consisting of 11 medicinal plants, including *Radix Astragali* and *Ginseng radix*. It has been used for over 30 years at the Jiangsu Provincial Hospital of Traditional Chinese Medicine in Nanjing, China, primarily for the treatment of bronchial asthma during the remission stage. The formula is derived from the classical TCM prescription Yu-Ping-Feng-San. GBFXT works through a multi-targeted mechanism that includes modulating the Th17/Treg immune balance to attenuate airway inflammation, suppressing endoplasmic reticulum (ER) stress responses by targeting proteins such as ORMDL3, BiP, and CHOP, and regulating lipid metabolism via activation of the AMPK pathway. Clinical and preclinical studies have demonstrated its ability to reduce airway hyperresponsiveness and decrease inflammatory cell infiltration in the lungs.
- Other names
- Guben Fangxiao DecoctionGuben Fangxiao YinGu-Ben-Fang-Xiao-Tang
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ORMDL3IL-17A (Interleukin-17A)IL10 (Interleukin-10)
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