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Gu Ben Hua Yu Formula

Development stage: Phase 1
Lead developer: Guangdong Provincial Hospital of Traditional Chinese Medicine
Modality: Small Molecules
Administration: Oral

Overview

Gu Ben Hua Yu Formula is a Traditional Chinese Medicine (TCM) herbal formulation developed by the Guangdong Provincial Hospital of Traditional Chinese Medicine for the treatment of moderate to severe psoriasis. It is a complex mixture of herbal ingredients designed to be administered orally. In clinical research, specifically a Phase 1/2 pilot study (NCT04785027), the formula is being evaluated in combination with expanded allogeneic adipose-derived mesenchymal stem cells (AD-MSCs). The treatment regimen involves daily oral administration of the formula alongside periodic intravenous infusions of AD-MSCs, aiming to leverage potential synergistic effects on immune modulation and skin lesion improvement.

Other names: Gu Ben Hua Yu

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)YAP1 (YES-associated protein–transcriptional enhancer factor domain complex)IL-17A (Interleukin-17A)IL-23 (Interleukin-23)TNFA (Tumor necrosis factor alpha (soluble))

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