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Guangdong Pharma Univ. FABP1 compound 44

Development stage
Preclinical
Lead developer
Guangdong Pharmaceutical University
01

Overview

Guangdong Pharma Univ. FABP1 compound 44: sourced facts only. name: "Herein, we firstly reported the comprehensive structure-activity relationship (SAR) study of novel FABP1 inhibitors derived from high throughput screening of our in-house library, which resulting in the identification of the optimal compound 44 (IC50 = 4.46 ± 0.54 μM)." [PMID:38574638]; target: "Herein, we firstly reported the comprehensive structure-activity relationship (SAR) study of novel FABP1 inhibitors derived from high throughput screening of our in-house library, which resulting in the identification of the optimal compound 44 (IC50 = 4.46 ± 0.54 μM)." [PMID:38574638]; developer: "School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China." [PMID:38574638]; stage: "Moreover, 44 alleviated the typical histological features of fatty liver in NASH mice, including steatosis, lobular inflammation, ballooning and fibrosis." [PMID:38574638]

02

Targets

FABP1 (Fatty acid-binding protein 1)

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