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Guangxi Normal Univ. 17β-HSD10 compound 14
- Development stage
- Preclinical
- Lead developer
- Guangxi Normal University
01
Overview
Guangxi Normal Univ. 17β-HSD10 compound 14: sourced facts only. name: "Compound 14 emerged as the lead candidate, demonstrating potent 17β-HSD10 inhibition (IC50 = 6.33 μM) and favorable blood-brain barrier permeability." [PMID:41747361]; target: "Compound 14 emerged as the lead candidate, demonstrating potent 17β-HSD10 inhibition (IC50 = 6.33 μM) and favorable blood-brain barrier permeability." [PMID:41747361]; developer: "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), Guangxi Normal University, Guilin City, Guangxi 541004, China." [PMID:41747361]; stage: "In APP/PS1 mice, compound 14 significantly improved cognitive function without affecting 17β-HSD10 protein levels." [PMID:41747361]
02
Targets
ABAD (17-beta-hydroxysteroid dehydrogenase type 10)
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