Guangxi Univ. TBC1D2 compound A1

Guangxi Univ. TBC1D2 compound A1: sourced facts only. name: "Surprisingly, TBC1 domain family member 2 (TBC1D2) emerged as the selective target of compound A1, which promotes Ras-related protein Rab-7a (RAB7A) accumulation on the lysosomal membrane and facilitates autophagy by inhibiting TBC1D2-mediated guanosine triphosphate (GTP) hydrolysis on RAB7A-GTP." [PMID:42172932]; target: "Surprisingly, TBC1 domain family member 2 (TBC1D2) emerged as the selective target of compound A1, which promotes Ras-related protein Rab-7a (RAB7A) accumulation on the lysosomal membrane and facilitates autophagy by inhibiting TBC1D2-mediated guanosine triphosphate (GTP) hydrolysis on RAB7A-GTP." [PMID:42172932]; developer: "School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China." [PMID:42172932]; stage: "Finally, A1 proved to be more efficient than matrine in HeLa-infected nude mice and was well-tolerated." [PMID:42172932]