Guangzhou Univ. of Chinese Medicine CYP11B1 compound 7aa

Guangzhou Univ. of Chinese Medicine CYP11B1 compound 7aa: sourced facts only. name: "Compound 7aa exhibited a highly potent CYP11B1 inhibition similar to that of the drug osilodrostat (IC50's of 9 and 6 nM, respectively) but was 1500-fold more selective over CYP11B2 compared to osilodrostat (selectivity factors of 125 versus 0.08, respectively)." [PMID:35975976]; target: "Compound 7aa exhibited a highly potent CYP11B1 inhibition similar to that of the drug osilodrostat (IC50's of 9 and 6 nM, respectively) but was 1500-fold more selective over CYP11B2 compared to osilodrostat (selectivity factors of 125 versus 0.08, respectively)." [PMID:35975976]; developer: "School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 232 East Waihuan Road, 510006 Panyu, Guangzhou, P. R. China." [PMID:35975976]; stage: "Strong reductions of plasma cortisol concentrations by compound 7aa were demonstrated in rats without interference in aldosterone production after oral application." [PMID:35975976]