guanosine

Guanosine is a purine nucleoside composed of the base guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. It is an endogenous molecule that can be phosphorylated to form GMP, cGMP, GDP, and GTP—key intermediates in signal transduction pathways and essential for nucleic acid synthesis, protein synthesis, photosynthesis (in plants), muscle contraction, and intracellular signaling. In biological systems, it plays roles in RNA splicing reactions and as a precursor for several antiviral drugs. Experimentally and preclinically, exogenous administration of guanosine has shown neuroprotective effects in models of central nervous system diseases such as ischemic stroke, Alzheimer's disease, Parkinson's disease, spinal cord injury, nociception (pain), and depression. Its neurobiological actions are thought to involve activation of intracellular signaling pathways and interaction with the adenosinergic system[1][2][3].

Other names

2-amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one2(3H)-imino-9-β-D-ribofuranosyl-9H-purin-6(1H)-one9-β-D-ribofuranosylguanineguanine ribosideguanine-9-beta-D-ribofuranosideguanine9-beta-D-ribofuranosideguanine 9-beta-D-ribofuranosideguanosinguanosinavernineGuanozin