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Guanxin Shutong Capsule
- Development stage
- Phase 4
- Lead developer
- Shanxi Buchang Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Guanxin Shutong Capsule (GXSTC) is a traditional Chinese medicinal formula composed of five herbal ingredients: Fructus Choerospondiatis (Guangzao), Salvia miltiorrhiza (Danshen), Flos Caryophylli (Dingxiang), Borneolum (Bingpian), and Concretio Silicea Bambusae (Tianzhuhuang)[1][2]. It has been clinically used in China for the treatment of coronary heart disease, angina pectoris, chest pain, depression, palpitation, and other cardiovascular diseases for nearly a decade[2][3][4][5][7]. Mechanistically, GXSTC exerts multi-target effects including antioxidative activity by reducing NADPH oxidase expression and oxidative stress markers; anti-inflammatory action by lowering interleukin-1β and interleukin-6 levels; endothelial protection via upregulation of endothelial nitric oxide synthase (eNOS) and increased nitric oxide production; inhibition of neuronal apoptosis; and modulation of vascular endothelial function[1][3][5]. Experimental studies have shown that GXSTC can reduce myocardial infarct size in animal models and improve neurological outcomes after cerebral ischemia[2][5].
- Brand names
- Guanxin Shutong Capsule
- Other names
- GXSTCGuan-Xin-Shu-Tong capsuleGuanxin-Shutong capsule
02
Targets
NOS3 (eNOS)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOX4 (NADPH oxidase 4)
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