Drug intelligence / Profile preview

Guanxinning

Development stage
Phase 2
Lead developer
ChiaTai Qingchunbao Pharmaceutical
Administration
Oral, Intravenous
01

Overview

Guanxinning is a Traditional Chinese Medicine (TCM) formulation primarily composed of extracts from *Salvia miltiorrhiza* (Danshen) and *Ligusticum chuanxiong* (Chuanxiong). It is widely used in China for the treatment of cardiovascular diseases, including coronary heart disease, angina pectoris, and coronary arterial microvascular disease. The drug works by promoting blood circulation, resolving blood stasis, and dilating coronary arteries, which improves myocardial blood supply and protects against ischemia-reperfusion injury. It is available in various forms, including tablets and injections, and is frequently evaluated in post-marketing clinical trials to confirm its efficacy in specific patient populations, such as those undergoing percutaneous coronary intervention (PCI).

Brand names
Guanxinning
Other names
Guanxinning TabletGuanxinning InjectionGuanxinningxin
02

Targets

Integrin alpha-M beta-2 – Platelet glycoprotein Ib alpha chain protein–protein interactionAKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR T790M (Epidermal growth factor receptor T790M mutant)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)MAPK14 (p38 mitogen-activated protein kinase alpha)

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