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Guanxinning Tablet

Development stage: Unknown
Lead developer: ChiaTai Qingchunbao Pharmaceutical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Guanxinning Tablet is a traditional Chinese medicine (TCM) formulation composed of extracts from *Salvia miltiorrhiza* (Danshen) and *Ligusticum chuanxiong* (Chuanxiong). It is an established treatment for stable exertional angina and is being investigated for its potential to improve coronary microcirculation in patients with acute ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PPCI). The tablet contains active components such as tanshinone IIA, salvianolic acid B, and tetramethylpyrazine, which provide anti-atherosclerotic effects through anti-inflammatory activity, inhibition of LDL oxidation, and suppression of vascular smooth muscle cell proliferation. Additionally, it offers microvascular protection by regulating autophagy and inhibiting apoptosis and platelet adhesion.

Brand names: Guanxinning Tablet
Other names: Guanxinning Tablets

Targets

MAPK14 (p38 mitogen-activated protein kinase alpha)EGFR T790M (Epidermal growth factor receptor T790M mutant)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)Macrophage-1 antigen – Platelet glycoprotein Ib alpha chain interface

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