Drug intelligence / Profile preview

Guanyu Jieyou Capsule

Development stage
Phase 2
Lead developer
Guangdong Liye Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Guanyu Jieyou Capsule is a Traditional Chinese Medicine (TCM) pharmaceutical product developed and manufactured by Guangdong Liye Pharmaceutical Co., Ltd. It is specifically indicated for the treatment of mild to moderate depression. The active ingredient is a standardized extract of *Hypericum perforatum* (St. John's Wort), which contains bioactive compounds such as hypericin and hyperforin. The drug's primary mechanism of action involves the non-selective inhibition of the reuptake of monoamine neurotransmitters, including serotonin (5-HT), norepinephrine (NE), and dopamine (DA), in the central nervous system. By increasing the synaptic availability of these neurotransmitters, it helps to regulate mood and emotional stability. It was approved by the China National Medical Products Administration (NMPA) and is often utilized as a natural alternative to synthetic selective serotonin reuptake inhibitors (SSRIs).

Brand names
Guanyu Jieyou CapsuleGuanyu Jieyou
Other names
贯叶解郁胶囊Hypericum perforatum extract capsuleSt. John's Wort extract capsule
02

Targets

PXR (Pregnane X receptor)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)SERT (Sodium-dependent serotonin transporter)TRPC6 (Transient receptor potential canonical type 6)

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