guava leaves extract mouthwash

Guava leaves extract mouthwash is an investigational botanical antimicrobial agent developed by Cairo University for the prevention and management of dental caries, particularly in high-risk patients. The formulation is derived from the leaves of the *Psidium guajava* plant and contains a complex mixture of bioactive compounds, including flavonoids (such as guaijaverin), tannins, phenolic acids, and antioxidants. Its primary mechanism of action involves the inhibition of *Streptococcus mutans*, the key bacterial species responsible for the initiation and progression of tooth decay. In clinical evaluations (NCT03773094), the mouthwash has demonstrated antibacterial efficacy comparable to the gold-standard chlorhexidine, while also being assessed for its impact on salivary pH and patient acceptability regarding taste.

Other names

Psidium guajava leaf extractGuava leaf extract