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guaxiexintong
- Development stage
- Unknown
- Lead developer
- Xiyuan Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Guaxiexintong is a traditional Chinese medicine (TCM) preparation developed by Xiyuan Hospital of the Chinese Academy of Chinese Medical Sciences for the treatment of chronic stable angina pectoris and coronary heart disease. Formulated as dropping pills, it is specifically indicated for patients presenting with the TCM syndrome of sputum stasis and blockage. The drug is currently in Phase II clinical development to evaluate its safety, efficacy, and optimal dosage in reducing the frequency of angina episodes and improving clinical symptoms. Its formulation is likely derived from classic TCM prescriptions such as Gualou Xiebai decoctions, which are traditionally used to resolve phlegm and unblock the chest.
- Brand names
- Guaxiexintong
- Other names
- Gua-Xie-Xin-TongGuaxiexintong dropping pills
02
Targets
BECN1 (Beclin-1)ERN1 (Inositol-requiring enzyme 1 alpha)XBP1 (X-box-binding protein 1)
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