guayusa

Guayusa is a **caffeinated herbal tea** derived from the leaves of the Ilex guayusa tree, native to the Ecuadorian Amazon and cultivated for thousands of years, especially among the Kichwa people[1][2][3]. Traditionally consumed as a morning beverage, it is used for its stimulating effects, believed to improve energy, alertness, mood, digestion, and immune function[1][2][3][4][5]. Guayusa contains several bioactive compounds, most notably **caffeine, theobromine, L-theanine, polyphenols (especially catechins), chlorogenic acid, ursolic acid, amyrins, and guanidine derivatives**[1][5]. Its main pharmacological activities are: - **Stimulant (caffeine, theobromine, L-theanine):** boosting mental and physical energy, concentration, and mood[1][2][5][7]. - **Antioxidant:** polyphenols and catechins combat oxidative stress and may help with chronic disease prevention[1][5]. - **Metabolic modulator:** caffeine and related compounds promote fat oxidation and weight loss; ursolic acid activates TGR5, which regulates lipid and glucose metabolism; guanidine derivatives act as hypoglycemic agents[1][5]. - **Anti-inflammatory and analgesic:** amyrins and caffeoylquinic acids suppress nitric oxide production and may reduce pain and inflammation[1]. - **Antimicrobial:** reported activity against some bacterial and protozoal agents[1]. Traditional and contemporary uses further include **appetite suppression, treating colic, menstrual discomfort, malaria, respiratory and digestive complaints, fertility issues**[1][2][3][4][5]. Guayusa is commercially available as dried whole leaves, tea bags, and as an ingredient in energy drinks and supplements[1].

Brand names

Ayusa

Other names

Ilex guayusa