Drug intelligence / Profile preview

guazuma ulmifolia extract

Development stage
Unknown
Lead developer
Universidade de São Paulo
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Guazuma ulmifolia extract is a botanical extract derived from the leaves, bark, or whole plant of *Guazuma ulmifolia* (commonly known as mutamba or bastard cedar). Rich in bioactive compounds such as proanthocyanidins, flavonoids, tannins, and saponins, the extract exhibits significant antioxidant, anti-inflammatory, and photoprotective properties. It has been traditionally used in Latin American and Indonesian folk medicine for weight loss, hair loss, and diabetes. Recent clinical and preclinical studies have investigated its potential in managing type 2 diabetes mellitus and obesity, as well as its application in cosmetic formulations (such as powder makeup) to provide broad-spectrum UV protection and combat oxidative stress.

Other names
Guazuma ulmifolia bark extractGuazuma ulmifolia leaf extractbastard cedar extractmutamba extract
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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