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guben huayu decoction

Development stage: Unknown
Lead developer: Guangdong Provincial Hospital of Traditional Chinese Medicine
Administration: Oral

Overview

Guben Huayu Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by the Guangdong Provincial Hospital of Chinese Medicine for the treatment of moderate-to-severe psoriasis. It is specifically indicated for patients exhibiting the 'blood-stasis' pattern, a TCM classification characterized by chronic, dark-colored plaques. The formula is designed to 'strengthen the foundation' (Guben) and 'resolve blood stasis' (Huayu). In clinical research, it has been evaluated in combination with methotrexate to improve clinical outcomes, such as the Psoriasis Area and Severity Index (PASI) score, and to modulate inflammatory pathways and the skin microbiome.

Other names: GBHYDGuben Huayu formula

Targets

MAPK3 (Mitogen-activated protein kinase 1)STAT3 (Signal Transducer and Activator of Transcription 3)JNK (Mitogen-activated protein kinase kinase kinase family)

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