Drug intelligence / Profile preview

Guben Kechuan

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral
01

Overview

Guben Kechuan is a traditional Chinese medicine (TCM) formula used for the treatment of chronic respiratory diseases such as bronchial asthma and chronic bronchitis. It is available in various formulations including granules, capsules, and tablets. The formula is clinically proven to relieve cough and clear phlegm. Mechanistically, it alleviates airway inflammation and remodeling by reducing inflammatory cell infiltration and decreasing levels of cytokines such as TNF-α, IL-4, IL-5, IL-6, and IL-10. Transcriptomic and proteomic studies indicate that its effects are mediated through inhibition of the NF-κB/STAT3 signaling pathway—reducing apoptosis (by lowering Bax/caspase-3 expression and increasing Bcl-2) as well as oxidative stress damage in lung tissue[1][7]. It has been used in China for over 20–30 years with an established safety profile[4][5].

Brand names
Guben KechuanGuben Kechuan granuleGuben Kechuan capsuleGuben Kechuan tablets
Other names
GK granuleGK capsuleGK tablets
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)NF-κB

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