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Guben Tongluo Fang
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Guben Tongluo Fang (固本通络方), also known as the Guben Tongluo formula or GTF, is a traditional Chinese medicine (TCM) prescription. It is primarily used for its protective effects in immunoglobulin A nephropathy (IgAN), an autoimmune kidney disease characterized by IgA immune complex deposition and mesangial cell proliferation. The mechanism of action involves modulation of the TLR4/MyD88/NF-κB signaling pathway in lamina propria B lymphocytes, which helps regulate immune responses and reduce pathological changes associated with IgAN. Studies indicate that it can decrease levels of pro-inflammatory markers and modulate immune cell activity[1][2][4]. The formula is composed of multiple herbal ingredients typical to TCM practice; however, the exact composition may vary by manufacturer.
- Brand names
- Guben Tongluo Fang
- Other names
- 固本通络方Guben Tongluo formulaGTF
02
Targets
NF-κBTLR4 (Toll-like receptor 4)MYD88 (Myeloid differentiation primary response protein MyD88)
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