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gui fu di huang
- Development stage
- Unknown
- Lead developer
- Beijing Anding Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gui Fu Di Huang is a classic Traditional Chinese Medicine (TCM) formula composed of eight herbal ingredients, primarily used to treat Kidney Yang deficiency. It is a modification of the Liu Wei Di Huang Wan formula, with the addition of *Cinnamomum cassia* (Rou Gui) and *Aconitum carmichaelii* (Fu Zi) to warm and invigorate the Yang. In the context of psychiatric research at Beijing Anding Hospital, it has been investigated as a treatment for depressive disorders, particularly those characterized by symptoms of fatigue, cold intolerance, and low mood associated with TCM-defined Kidney Yang deficiency. The formula is thought to modulate the hypothalamic-pituitary-adrenal (HPA) axis and neurotransmitter levels, though its exact molecular mechanism is complex due to its multi-component nature.
- Brand names
- Gui Fu Di Huang WanJin Kui Shen Qi Wan
- Other names
- Shen Qi WanKidney Qi PillRehmannia Eight Formula
02
Targets
CRH (Corticotropin-Releasing Factor)GR (Glucocorticoid receptor)BDNF (Brain-derived neurotrophic factor)
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