Drug intelligence / Profile preview

gui-lu-er-xian-jiao-wan

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral
01

Overview

Gui-Lu-Er-Xian-Jiao-Wan is a traditional Chinese medicine (TCM) formula composed primarily of animal-derived gelatin (from tortoise shell and deer antler), Lycium fruit (goji berry), and red ginseng. It is traditionally used to tonify energy (qi) and spirit, nourish blood and yin, benefit the kidneys and liver, improve vision, support musculoskeletal health, promote circulation, address menopausal syndrome symptoms, osteoporosis, endocrine imbalances, impotence due to kidney deficiency or weakness/debility in elderly patients[2][8]. Modern research suggests it may enhance muscle strength by upregulating protein synthesis pathways (IGF-1/IGF-1R/IRS-1/Akt), improving glucose homeostasis via Glut4 translocation in skeletal muscle cells[4], supporting mitochondrial biogenesis (PGC-1a/NRF1/TFAM), increasing slow-twitch muscle fibers[4], reducing articular pain in osteoarthritis[7][1], alleviating chemotherapy-induced side effects such as weight loss or bone loss[5], and potentially improving intradialytic hypotension. The product is available as capsules or syrup.

Brand names
Gui Lu Er Xian WanGui Lu Er Xian JiaoGuilu Erxian JiaoGuilu Erxian Glue
Other names
Testudinis & Antler CombinationTortoise Shell and Deer Antler Two Immortals SyrupDeer and Turtle Two Immortals Gelatin Magic Glue of Tortoise Plastron and Antler Horn
02

Targets

IGF-1R (Insulin-like growth factor 1 receptor)PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)

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