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Guiding Phlegm Decoction

Development stage
Preclinical
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Guiding Phlegm Decoction (Dao Tan Tang, 导痰汤) is a traditional Chinese herbal formula used in Traditional Chinese Medicine (TCM) to address conditions associated with "phlegm" accumulation and internal wind. It is typically prescribed for symptoms such as dizziness, accumulation of phlegm rheum, fullness of the chest and diaphragm, distention of the hypochondrium, headache and vomiting, panting and cough with expectoration, sticky snivel or saliva, a thick greasy tongue coating, and a slippery pulse. The formula works by drying dampness and removing phlegm while moving qi (vital energy) to open constraint. Its classical ingredients include Pinellia ternata (Ban Xia), Arisaema consanguineum (Tian Nan Xing), Citrus aurantium (Zhi Shi), Citrus reticulata peel (Ju Hong), Poria cocos var. rubra (Chi Fu Ling), often prepared with fresh ginger. The mechanism is based on TCM theory rather than modern pharmacology; it aims to resolve phlegm obstruction in the body by harmonizing digestive function and fluid metabolism[1][6].

Brand names
Guiding Phlegm Decoction
Other names
Dao Tan Tang导痰汤Phlegm-Expelling Decoction
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HSP90AA1 (Heat shock protein HSP90-alpha)TP53 (Cellular Tumor Antigen p53 R175H)MAPK3 (Mitogen-activated protein kinase 1)

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