Drug intelligence / Profile preview

guifu dihuang pill

Development stage
Unknown
Lead developer
Hospital of Chengdu University of Traditional Chinese Medicine
Administration
Oral
01

Overview

Guifu Dihuang pill is a classic Traditional Chinese Medicine (TCM) formula designed to warm and tonify kidney yang. It is composed of eight herbs: prepared Rehmannia root, Cornus fruit, Yam, Poria, Alisma, Moutan bark, Cinnamon bark, and prepared Aconite. The formula is a modification of the Liuwei Dihuang pill, specifically adding Cinnamon and Aconite to address yang deficiency. It is widely used in China for treating symptoms such as cold extremities, lower back pain, frequent urination (especially nocturia), and impotence. Clinical research, including Phase 4 trials, has evaluated its efficacy in managing nocturia associated with kidney yang deficiency syndrome in elderly populations.

Brand names
Guifu Dihuang Wan
Other names
Guifu Dihuang pillJingui Shenqi WanKidney Qi PillCinnamon and Aconite Pill with Rehmannia
02

Targets

ERKMUC5AC (Mucin-5AC)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)NRCAM (Neuronal cell adhesion molecule)EGFR T790M (Epidermal growth factor receptor T790M mutant)AKT (RAC-alpha serine/threonine-protein kinase)SP1 (Specificity protein 1 (SP1) and related GC-box binding transcription factors)

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