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Guifu Erxian Decoction is a Traditional Chinese Medicine (TCM) herbal formula being evaluated for the treatment of chronic hepatitis B. Developed by the Xi'an Traditional Medicine Hospital, the decoction is designed to address the TCM syndrome of 'Yang deficiency of spleen and kidney.' In clinical research, it is typically administered as an 'Advanced' TCM intervention in combination with standard-of-care antiviral therapies such as entecavir or tenofovir. The formula aims to improve TCM-related symptoms (e.g., hypochondriac pain, jaundice) and potentially delay hepatic fibrosis. As a botanical mixture, its specific molecular targets are not well-defined in Western pharmacological terms, but it functions through a multi-component approach characteristic of herbal decoctions.
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