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Guilu Sanhuang Decoction is a Traditional Chinese Medicine (TCM) herbal formulation currently under investigation for its potential to address abnormal bone metabolism following endocrine therapy for breast cancer. The name "Guilu Sanhuang" suggests a combination of ingredients, with "Guilu" (tortoise and deer) typically referring to components like tortoise shell and deer antler, traditionally used in TCM for strengthening bones and kidneys. The "Sanhuang" (three yellow) component, in the context of related decoctions, often refers to herbs such as astragalus, turmeric, and rhubarb. As a decoction, it is administered orally and is believed to exert its therapeutic effects through multiple mechanisms, common to TCM for bone health, including the regulation of bone formation and resorption, modulation of oxidative stress, and influence on various signaling pathways.
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