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Guipi Anshuiyin
- Development stage
- Preclinical
- Lead developer
- Shenzhen Hospital of Beijing University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Guipi Anshuiyin is a Traditional Chinese Medicine (TCM) formulation developed by the Shenzhen Hospital of Beijing University of Chinese Medicine (Longgang) for the treatment of chronic insomnia. The formula is specifically designed for patients exhibiting the "Heart and Spleen Deficiency" pattern, a common TCM diagnosis for sleep disorders. It is derived from the classical *Guipi Tang* (Spleen-Restoring Decoction) and incorporates additional herbs to enhance its sedative and "spirit-calming" (An Shen) properties. The mechanism of action involves the synergistic effect of multiple botanical compounds that are thought to modulate the central nervous system, potentially through the GABAergic and serotonergic pathways, to improve sleep architecture, reduce sleep latency, and alleviate daytime fatigue.
- Other names
- 归脾安睡饮Guipi Anshui Decoction
02
Targets
PDE4APDE4B (3',5'-cyclic-AMP phosphodiesterase 4B)
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