Drug intelligence / Profile preview

Guipi Decoction Mimetic

Development stage
Preclinical
Administration
Oral
01

Overview

Guipi Decoction Mimetic refers to a formulation designed to mimic the traditional Chinese medicine (TCM) formula known as "Guipi decoction" or "Gui Pi Tang." The original Guipi decoction is a multi-herb blend used in TCM for tonifying Qi and Blood, strengthening the Spleen, and nourishing the Heart. It is widely used for conditions such as insomnia, depression, anxiety, palpitations, fatigue, poor appetite, and chronic heart failure. The mimetic version would be intended to reproduce these effects using either similar herbal components or alternative substances that replicate its pharmacological actions. Mechanistically, the original formula acts through multiple pathways: - Modulation of neurotransmitters (e.g., serotonin/dopamine) relevant to mood and sleep - Anti-inflammatory effects - Antioxidant activity - Improvement of cardiac function by reducing N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and improving left ventricular ejection fraction[7][8] - Regulation of immune response[2][7][8] The mimetic would aim to achieve similar multi-targeted actions. Indications include insomnia[1], depression[2][5][6], chronic heart failure[7][8], anxiety[9], anemia[3], anorexia[3], palpitations[4], fatigue/weakness due to Spleen/Heart deficiency syndromes in TCM.

Brand names
Guipi Decoction Mimetic
Other names
Guipi Decoction Mimetic
02

Targets

SERT (Sodium-dependent serotonin transporter)DRD2 (Dopamine D2 Receptor)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)

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