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Guiyuan Tablet
- Development stage
- Phase 3
- Lead developer
- Yabao Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Guiyuan Tablet is a Traditional Chinese Medicine (TCM) product developed by Shanxi Yabao Pharmaceutical Group for the management of opioid withdrawal syndrome and dependence. The formulation is a complex mixture of herbal extracts, with *Corydalis yanhusuo* being a key component due to its high content of l-tetrahydropalmatine (l-THP). l-THP acts as a potent antagonist at dopamine D1, D2, and D3 receptors, which is believed to mitigate the dopaminergic surges associated with drug craving and withdrawal. Other ingredients like *Panax ginseng* and *Aconitum carmichaelii* are included to provide systemic support and alleviate physical symptoms such as pain and fatigue. Guiyuan Tablet has been approved in China and is used as a non-opioid alternative for detoxification in patients with heroin or other opioid addictions.
- Brand names
- Guiyuan Tablet
- Other names
- Guiyuan PianGui Yuan Tablet
02
Targets
DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)MOR (Mu opioid receptor)
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