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Guizhi Tangju

Development stage: Unknown
Lead developer: Tang Beining Pharmaceutical Technology
Modality: Small Molecules
Administration: Topical

Overview

Guizhi Tangju is a proprietary Traditional Chinese Medicine (TCM) formulation developed by Tang Beining Pharmaceutical Technology (Beijing) Co., Ltd. for the treatment of diabetic foot ulcers (DFU). It is a modified version of the classical Guizhi Tang (Cinnamon Twig Decoction), optimized for topical application to chronic wounds. The drug is designed to address the complex pathology of diabetic foot complications by improving peripheral microcirculation, modulating the local inflammatory response, and promoting tissue regeneration and wound healing. It is currently being evaluated in clinical trials to assess its efficacy in accelerating ulcer closure and reducing the risk of infection in diabetic patients.

Brand names: Guizhi Tangju
Other names: 桂枝汤聚Guizhi Tang Ju

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)RELA (Nuclear Factor Kappa B Subunit p65)VEGFA (Vascular endothelial growth factor A)MAPK14 (p38 mitogen-activated protein kinase alpha)ESR1 (ERα)IL1B (Interleukin-1 beta)TP53 (Cellular Tumor Antigen p53 R175H)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)PDE5A (Cyclic GMP-specific phosphodiesterase 5A)IL-6 (Interleukin 6)MAPK3 (Mitogen-activated protein kinase 1)

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