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Guizhi Tangju
- Development stage
- Phase 2
- Lead developer
- Tang Beining Pharmaceutical Technology
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Guizhi Tangju is a proprietary Traditional Chinese Medicine (TCM) formulation developed by Tang Beining Pharmaceutical Technology (Beijing) Co., Ltd. for the treatment of diabetic foot ulcers (DFU). It is a modified version of the classical Guizhi Tang (Cinnamon Twig Decoction), optimized for topical application to chronic wounds. The drug is designed to address the complex pathology of diabetic foot complications by improving peripheral microcirculation, modulating the local inflammatory response, and promoting tissue regeneration and wound healing. It is currently being evaluated in clinical trials to assess its efficacy in accelerating ulcer closure and reducing the risk of infection in diabetic patients.
- Brand names
- Guizhi Tangju
- Other names
- 桂枝汤聚Guizhi Tang Ju
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)MAPK14 (p38 mitogen-activated protein kinase alpha)MAPK3 (Mitogen-activated protein kinase 1)PDE5 (Phosphodiesterase 5A)RELA (Nuclear Factor Kappa B Subunit p65)STAT3 (Signal Transducer and Activator of Transcription 3)TP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)
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