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Guizhou Univ. EGFR compound 6e
- Development stage
- Unknown
- Lead developer
- Guizhou University
01
Overview
Guizhou Univ. EGFR compound 6e: sourced facts only. name: "Furthermore, compounds 6e and 9i showed extraordinary activity against EGFR19del/T790M/C797S (IC50 = 16.06 nM and 37.95 nM) and EGFRL858R/T790M/C797S (IC50 = 11.81 nM and 26.68 nM), which were potent than Osimertinib (IC50 = 52.28 nM and 157.60 nM)." [PMID:38169271]; target: "Furthermore, compounds 6e and 9i showed extraordinary activity against EGFR19del/T790M/C797S (IC50 = 16.06 nM and 37.95 nM) and EGFRL858R/T790M/C797S (IC50 = 11.81 nM and 26.68 nM), which were potent than Osimertinib (IC50 = 52.28 nM and 157.60 nM)." [PMID:38169271]; developer: "School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China." [PMID:38169271]; stage: "In vivo xenograft mouse model with HCC827 cells, compound 6e resulted in remarkable tumor regression without obvious toxicity." [PMID:38169271]
02
Targets
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