Guizhou Univ. FAK compound 16c

Guizhou Univ. FAK compound 16c: sourced facts only. name: "Among the synthesized derivatives, compound 16c distinguished itself as a highly potent inhibitor, showing an IC50 value of 5.8 nM against FAK and robust antiproliferative activities in U87-MG (IC50 = 6.6 nM) and U118-MG (IC50 = 4.3 nM) GBM cell lines." [PMID:42019175]; target: "Among the synthesized derivatives, compound 16c distinguished itself as a highly potent inhibitor, showing an IC50 value of 5.8 nM against FAK and robust antiproliferative activities in U87-MG (IC50 = 6.6 nM) and U118-MG (IC50 = 4.3 nM) GBM cell lines." [PMID:42019175]; developer: "School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China." [PMID:42019175]; stage: "Importantly, the oral bioavailability of 16c reached 18.7% at a dose of 10 mg/kg, and 16c displayed pronounced antitumor efficacy in the absence of detectable systemic toxicity in a U87-MG xenograft model." [PMID:42019175]