Guizhou Univ. FAK compound 9f

Guizhou Univ. FAK compound 9f: sourced facts only. name: "Among these compounds, 9f emerged as a potent dual inhibitor, demonstrating exceptional inhibitory activity against FAK (IC50 = 0.815 nM) and DNA, as well as remarkable antiproliferative effects on glioblastoma cell lines U87-MG (IC50 = 15 nM) and U251 (IC50 = 20 nM)." [PMID:39832391]; target: "Among these compounds, 9f emerged as a potent dual inhibitor, demonstrating exceptional inhibitory activity against FAK (IC50 = 0.815 nM) and DNA, as well as remarkable antiproliferative effects on glioblastoma cell lines U87-MG (IC50 = 15 nM) and U251 (IC50 = 20 nM)." [PMID:39832391]; developer: "School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China." [PMID:39832391]; modality: "In this study, we report design and synthesis of a novel series of diaminopyrimidine-based small molecules that concurrently target both FAK and DNA." [PMID:39832391]; stage: "Notably, in a U87-MG xenograft model, compound 9f exhibited superior antitumor efficacy." [PMID:39832391]