Drug intelligence / Profile preview

Gujin Granule

Development stage
Unknown
Lead developer
Beijing Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Gujin Granule is a multi-component Traditional Chinese Medicine (TCM) formulation developed primarily for the treatment of non-small cell lung cancer (NSCLC). Developed by the Beijing Hospital of Traditional Chinese Medicine, it is a modern preparation of a classic formula designed to "strengthen the lungs" (Gold/Metal in TCM theory) and detoxify the body. The granule is typically used as an adjuvant therapy alongside platinum-based chemotherapy or targeted therapies. Its pharmacological profile is multi-targeted, involving the modulation of the immune microenvironment by enhancing CD4+ T-cell and Natural Killer (NK) cell activity, and the inhibition of tumor growth through the suppression of angiogenesis and induction of apoptosis. Clinical studies suggest that Gujin Granule can significantly reduce the side effects of chemotherapy, improve quality of life, and potentially extend progression-free survival in patients with advanced lung cancer.

Brand names
Gujin Granule
Other names
Gujin FormulaGJKLGu-Jin Granule
02

Targets

AKR1B10 (Aldo-keto reductase family 1 member B10)AKR1C2 (Aldo-keto reductase family 1 member C2)

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