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GVB-2001
- Development stage
- Phase 2
- Lead developer
- IVIEW Therapeutics
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Gene Silencing → Gene Therapies, Gene Editing → Gene Therapies
- Administration
- Intracameral
01
Overview
GVB-2001 is a self-complementary adeno-associated viral vector (scAAV) gene therapy designed for the treatment of primary open-angle glaucoma. It works by delivering the human dominant-negative RhoA (dnRhoA) gene to the trabecular meshwork cells of the eye via intracameral injection. The dnRhoA gene specifically targets and inhibits the Rho-associated coiled-coil containing protein kinase (ROCK) signaling pathway, which regulates intraocular pressure (IOP). Inhibiting this pathway can facilitate aqueous humor outflow, thereby reducing IOP—a critical factor in glaucoma management. GVB-2001 is being developed and clinically evaluated by iVIEW Therapeutics[1][4][5][10].
- Brand names
- GVB-2001GVB2001GVB 2001
- Other names
- ScAAV2-dnRhoAScAAV-2-dnRhoAScAAV 2-dnRhoA
02
Targets
ROCK1 (Rho-associated coiled-coil containing protein kinase 1)
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