GW0742

GW0742 is a **synthetic, potent, and selective agonist** of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ), a member of the nuclear hormone receptor family. It acts primarily as a **PPARβ/δ agonist** but can function as a mixed agonist/antagonist at other nuclear receptors depending on dosage. GW0742 is antagonistic at the androgen receptor and vitamin D receptor (VDR), and in silico studies suggest effects on thyroid hormone receptors. Developed by GlaxoSmithKline, GW0742 has been used almost exclusively as a pharmacological tool compound in preclinical studies, with no current approved therapeutic uses. Research has demonstrated **antidiabetic, anti-inflammatory, and antihypertensive effects** in animal models, including improved insulin resistance, mitigation of liver damage, reduced neuroinflammation, protection of cardiac and vascular function, and support for metabolic homeostasis[1][3][4][6][7][8][10].

Other names

fitorine