GW280264X

GW280264X is a **potent dual inhibitor** of the metalloproteinases **ADAM10** and **ADAM17 (also known as TACE)**. It is a small molecule, classified as a hydroxamate derivative, and inhibits ADAM17 with an IC50 of 8.0 nM and ADAM10 with an IC50 of 11.5 nM[1][3][7][11]. These proteases are implicated in the shedding of multiple cell surface proteins, modulating signaling cascades relevant to oncogenesis and immune regulation. GW280264X is used widely in preclinical research to dissect the roles of ADAM10 and ADAM17, especially in cancer models. It has shown activity in vitro and in animal studies, including enhancement of platinum chemotherapy efficacy and synergy with PARP inhibitors like olaparib in ovarian cancer[2][5][6]. It is not approved for therapeutic use and is supplied for laboratory research only.