GW406381

GW406381 is a highly selective cyclooxygenase‐2 (COX‐2) inhibitor developed as an investigational small molecule for the treatment of inflammatory pain and related conditions. It has demonstrated both peripheral and central actions, with relatively high CNS penetration. Clinical trials have evaluated its efficacy in acute migraine, postherpetic neuralgia, osteoarthritis of the knee, rheumatoid arthritis, dental pain, trauma-related pain, neurodynia, and hyperalgesia. In clinical studies for acute migraine and neuropathic pain (postherpetic neuralgia), it showed some efficacy but did not consistently reach statistical significance over placebo in all endpoints. The drug was generally well tolerated in studied populations[1][6][8][9][10].

Other names

2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]pyrazolo[1,5-b]pyridazine221148-46-5CHEMBL364804CHEMBL-364804CHEMBL 364804compound 8 [PMID:15454242]GW 406381XGW406381XGW-406381X