GW7845

**GW7845** is a synthetic small molecule acting as a potent and selective agonist of the nuclear receptor peroxisome proliferator-activated receptor gamma (**PPARγ**), which is involved in regulating metabolism, fatty acid β-oxidation, glucose utilization, cholesterol transport, and cellular differentiation[1][2][3][4][5][7][9]. GW7845 is also an L-tyrosine derivative, chemically described as (2S)-2-[(2-methoxycarbonylphenyl)amino]-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid[1][5]. Preclinical studies demonstrate that GW7845 can induce apoptosis, limit migration of cancer cells[3][8][10], and delay tumor formation (notably, in mouse mammary tumor models)[4][6]. GW7845 enhances expression of PPARγ-responsive genes, redirects macrophage cholesterol efflux to adipose tissue via SR-BI, and affects mitochondrial function, indicating a multifaceted role in cellular metabolism, signaling, and cancer biology[2][4][6][10]. GW7845 is used widely in research but not approved for therapeutic use in humans or animals[1].

Other names

GW7845GW-7845GW 7845