GW9662

GW9662 (2-chloro-5-nitro-N-phenylbenzamide) is a synthetic small molecule that acts as an irreversible antagonist of the peroxisome proliferator–activated receptor gamma (PPARγ). It binds covalently to the ligand-binding domain of PPARγ, thereby inhibiting its transcriptional activity. This compound is widely used in research to study PPARγ function and signaling pathways, particularly in metabolic diseases, inflammation, and cancer biology. It is not approved for clinical use and serves primarily as a pharmacological tool in experimental settings[1][7].

Other names

2-chloro-5-nitro-N-phenylbenzamide2-Chloro-5-nitrobenzanilideCS-762CS762CS 762TIMTEC-BB SBB006523