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GX-70
- Development stage
- Phase 1
- Lead developer
- Genexine
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
GX-70 is an investigational DNA vaccine developed by Genexine for the treatment of pulmonary tuberculosis and the prevention of disease relapse. The vaccine is composed of four plasmids encoding antigens derived from *Mycobacterium tuberculosis* (MTB) and a fifth plasmid encoding the Fms-related tyrosine kinase 3 ligand (Flt3L), which acts as a genetic adjuvant to stimulate dendritic cell maturation and enhance the cellular immune response. GX-70 was intended for use in patients with high-risk factors for treatment failure or relapse, such as those with cavitary disease or persistent sputum positivity. A Phase 1 clinical trial (NCT03159975) was planned in South Korea but was withdrawn prior to the enrollment of participants.
- Other names
- GX-70GX70GX 70
02
Targets
FLT3LG (FLT3 ligand)
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