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gynostemma pentaphyllum total glycoside granules
- Development stage
- Unknown
- Lead developer
- Changzhou Sports Hospital
- Administration
- Oral
01
Overview
Gynostemma pentaphyllum total glycoside granules are a botanical drug product derived from the herb *Gynostemma pentaphyllum* (Jiaogulan). The primary active components are gypenosides, which are dammarane-type saponins structurally similar to ginsenosides. These glycosides are known to activate adenosine monophosphate-activated protein kinase (AMPK), a key regulator of lipid and glucose metabolism. In clinical settings, particularly in China, it is used to treat dyslipidemia and non-alcoholic fatty liver disease (NAFLD) by lowering non-HDL cholesterol and triglycerides while improving cardiovascular function. The granule formulation is intended for oral administration and is often studied in combination with lifestyle interventions like scientific exercise.
- Other names
- GypenosidesGynostemma pentaphyllum total saponinsJiaogulan total glycoside granules
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)KATP channel (ATP-sensitive potassium channel)FOXO1 (Forkhead box protein O1)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)NF-κBPPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)mTOR (Mammalian target of rapamycin kinase)RK (Ribokinase)
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