Drug intelligence / Profile preview

Gyntima Balance

Development stage
Unknown
Lead developer
AB-BIOTICS
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Gyntima Balance is a probiotic nutraceutical developed by AB-BIOTICS (a subsidiary of Kaneka) designed to address vaginal microbiota imbalance, vaginal discomfort, and the need for urogenital immune support. The product is a combination of the active probiotic strain *Lactobacillus gasseri* KABP-064 (also designated CECT 30648) along with biotin, selenium, zinc, and vitamin D. It operates via the oral-gut-vagina axis, where the probiotic strain survives gastrointestinal transit to colonize the vaginal tract. Its primary mechanism of action is the modulation of the vaginal microbiome, shifting dysbiotic Community State Types toward healthy, *Lactobacillus*-dominated vaginotypes. Clinical studies have demonstrated that oral administration enables vaginal colonization in a majority of healthy premenopausal women and exhibits inhibitory activity against common urogenital pathogens, including bacteria and yeast.

Brand names
Gyntima Balance
Other names
Lactobacillus gasseri KABP-064Lactobacillus gasseri CECT 30648
02

Targets

VDR (Vitamin D receptor)VMB (Vaginal microbiome community structure)

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