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Gyntima Menopause
- Development stage
- Unknown
- Lead developer
- AB-BIOTICS
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Gyntima Menopause (also known as KABP Menopause) is a proprietary three-strain probiotic formula developed by AB-BIOTICS, a subsidiary of the Kaneka Group. The product contains three patented bacterial strains: *Levilactobacillus brevis* KABP 052, *Lactiplantibacillus plantarum* KABP 051, and *Pediococcus acidilactici* KABP 021. It is designed to target the estrobolome—the gut microbiota responsible for metabolizing estrogens—by increasing gut β-glucuronidase activity. This enzymatic action deconjugates estrogens in the gut, allowing for their reabsorption into the bloodstream and thereby modulating systemic estrogen levels. Clinical evidence supports its use in improving menopause-related symptoms such as hot flashes, sleep disturbances, and depressive mood in peri- and postmenopausal women.
- Brand names
- Gyntima Menopause
- Other names
- KABP MenopauseGyntima® Menopause
02
Targets
GUSB (Beta-glucuronidase)
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