gypenoside L

Gypenoside L is a dammarane-type saponin isolated from the herbaceous vine *Gynostemma pentaphyllum* (Jiaogulan). It has been investigated for its anti-proliferative and anti-tumor properties, particularly in preclinical models of human liver and esophageal cancer. The compound acts by inducing cellular senescence and S-phase cell cycle arrest, rather than immediate apoptosis. This effect is mediated through the activation of the p38 and ERK mitogen-activated protein kinase (MAPK) pathways, as well as the NF-κB signaling pathway, which subsequently upregulates the senescence-related cyclin-dependent kinase inhibitors p21 and p27. Preclinical studies also suggest that gypenoside L can act as a chemosensitizer, enhancing the cytotoxicity of standard chemotherapeutic agents such as 5-fluorouracil and cisplatin.

Other names

Gyp-L