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GZR18 + digoxin + rosuvastatin calcium + warfarin sodium

Development stage: Unknown
Lead developer: Gan & Lee Pharmaceuticals
Modality: Peptides, Small Molecules
Administration: Subcutaneous, Oral

Overview

This drug combination is utilized in a Phase 1 clinical trial conducted by Gan & Lee Pharmaceuticals to evaluate the pharmacokinetic drug-drug interactions (DDI) and the effect on gastric emptying of GZR18 (bofanglutide) in obese or overweight subjects. GZR18 is a long-acting, bi-weekly glucagon-like peptide-1 (GLP-1) receptor agonist designed for weight management and type 2 diabetes. In this specific regimen, GZR18 is co-administered with three probe substrates: digoxin (a P-glycoprotein substrate), rosuvastatin calcium (an OATP1B1/1B3 substrate), and warfarin sodium (a CYP2C9 substrate). The study aims to determine if the delayed gastric emptying caused by GZR18 significantly alters the absorption or systemic exposure of these commonly prescribed medications.

Other names: bofanglutide + digoxin + rosuvastatin calcium + warfarin sodium

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)VKORC1 (Vitamin K epoxide reductase complex subunit 1)GLP1R (GLP-1R)

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